Effect of inactivation by hydroxylamine on early functions of poliovirus.
نویسندگان
چکیده
Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.
منابع مشابه
Early functions of poliovirus. II. The RNA replication of hydroxylamine-inactivated polioviruses.
If cells are exposed to a mixture of hydroxylamine inactivated and infectious viruses the total rate of viral RNA-replication is lower than if the cells are infected with the same number of infectious viruses alone. This inhibitory influence of inactivated viruses depends on the ratio of infectious: inactivated viruses in the inoculum. One lethal hit by hydroxylamine suffices to produce the eff...
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عنوان ژورنال:
- Journal of virology
دوره 8 1 شماره
صفحات -
تاریخ انتشار 1971